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008200131s2019 ||||||||||||||||| ||eng d
020 ▼a 9781392522974
035 ▼a (MiAaPQ)AAI22622958
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 247004
0820 ▼a 615
1001 ▼a Vuu, Irene.
24510 ▼a Development of Parenteral Drugs for the Treatment of Seizure Emergencies.
260 ▼a [S.l.]: ▼b University of Minnesota., ▼c 2019.
260 1 ▼a Ann Arbor: ▼b ProQuest Dissertations & Theses, ▼c 2019.
300 ▼a 233 p.
500 ▼a Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
500 ▼a Advisor: Cloyd, James C
5021 ▼a Thesis (Ph.D.)--University of Minnesota, 2019.
506 ▼a This item must not be sold to any third party vendors.
506 ▼a This item must not be added to any third party search indexes.
520 ▼a The overall objective of my dissertation is to develop alternative therapies for seizure emergencies. Status epilepticus is a condition defined as a convulsive seizure lasting more than 5 minutes and is considered a seizure emergency due to the increased risk for neuronal damage and mortality (Trinka et al. 2015). Although relatively effective, first-line therapy fails to terminate status epilepticus in 26-57% of cases, leading to increased risk of seizure refractoriness and use of second- and third-line therapies that may increase the risk of systemic complications and mortality (Treiman et al. 1998
590 ▼a School code: 0130.
650 4 ▼a Pharmaceutical sciences.
690 ▼a 0572
71020 ▼a University of Minnesota. ▼b Experimental & Clinical Pharmacology.
7730 ▼t Dissertations Abstracts International ▼g 81-04B.
773 ▼t Dissertation Abstract International
790 ▼a 0130
791 ▼a Ph.D.
792 ▼a 2019
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T15493953 ▼n KERIS ▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다.
980 ▼a 202002 ▼f 2020
990 ▼a ***1816162
991 ▼a E-BOOK