| LDR | | 00000nam u2200205 4500 |
| 001 | | 000000435934 |
| 005 | | 20200228111227 |
| 008 | | 200131s2018 ||||||||||||||||| ||eng d |
| 020 | |
▼a 9781085757775 |
| 035 | |
▼a (MiAaPQ)AAI13425131 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 575 |
| 100 | 1 |
▼a Miller, Jeffrey Thomas. |
| 245 | 10 |
▼a Mapping the Genetic Basis of Rapid Evolution to Industrial Pollutants in Atlantic Killifish (Fundulus heteroclitus). |
| 260 | |
▼a [S.l.]:
▼b University of California, Davis.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 89 p. |
| 500 | |
▼a Source: Dissertations Abstracts International, Volume: 81-04, Section: B. |
| 500 | |
▼a Advisor: Whitehead, Andrew. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of California, Davis, 2018. |
| 506 | |
▼a This item must not be sold to any third party vendors. |
| 506 | |
▼a This item must not be added to any third party search indexes. |
| 520 | |
▼a Multiple populations of Atlantic Killifish (Fundulus heteroclitus) that reside in heavily polluted habitats along the Atlantic coast of North America have repeatedly and rapidly evolved resistance to highly toxic dioxin-like pollutants (DLCs), which act through the aryl hydrocarbon receptor (AHR) signaling pathway. A multi-population genome-wide scan showed that wild DLC-resistant killifish populations have some shared and some unique genomic regions under selection. These studies and others suggest that resistance to the toxic effects of DLCs, such as cardiovascular and other developmental deformities, is extreme but not identical in resistant killifish populations. Here, we extended the QTL (Quantitative-Trait Locus) approach to four resistant killifish populations distributed from Massachusetts to Virginia and employed high-density QTL interval mapping to compare and contrast genetic regions associated with DLC resistance in these diverse populations. Our results show that in all four populations, a common genomic region associates with DLC resistance. This region includes two AHR pathway genes (AHR1b/2b) that did not show obvious signatures of selection in population genome scan data. Conversely, another AHR pathway gene (AIP) falls in a genomic region showing strong signatures of selection and associates with resistance in three of the four of our mapping populations. These results also suggest that variation in AHR1b/2b may have evolved by soft sweeps on standing genetic variation in resistant populations, which are difficult to detect by traditional selection scan methods. These results also suggest that AIP is an important component in the evolutionary response to complex, heavily contaminated environments. Our findings, integrated with population genomic scans for selection, reveal the unique evolutionary trajectories that led to evolved DLC resistance in wild killifish. |
| 590 | |
▼a School code: 0029. |
| 650 | 4 |
▼a Evolution & development. |
| 650 | 4 |
▼a Genetics. |
| 690 | |
▼a 0412 |
| 690 | |
▼a 0369 |
| 710 | 20 |
▼a University of California, Davis.
▼b Pharmacology and Toxicology. |
| 773 | 0 |
▼t Dissertations Abstracts International
▼g 81-04B. |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0029 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15490427
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 202002
▼f 2020 |
| 990 | |
▼a ***1816162 |
| 991 | |
▼a E-BOOK |