| LDR | | 00000nam u2200205 4500 |
| 001 | | 000000436764 |
| 005 | | 20200228152721 |
| 008 | | 200131s2019 ||||||||||||||||| ||eng d |
| 020 | |
▼a 9781088310588 |
| 035 | |
▼a (MiAaPQ)AAI10746594 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 616.99 |
| 100 | 1 |
▼a Apple, Alexandra Clemans. |
| 245 | 14 |
▼a The Role of the Hippocampal-prefrontal Network in Cancer-related Cognitive Impairment: A Multimodal Cross-sectional Study. |
| 260 | |
▼a [S.l.]:
▼b Northwestern University.,
▼c 2019. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2019. |
| 300 | |
▼a 112 p. |
| 500 | |
▼a Source: Dissertations Abstracts International, Volume: 81-04, Section: B. |
| 500 | |
▼a Advisor: Wang, Lei. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Northwestern University, 2019. |
| 506 | |
▼a This item must not be sold to any third party vendors. |
| 506 | |
▼a This item must not be added to any third party search indexes. |
| 520 | |
▼a Between 30-75% of cancer patients receiving adjuvant therapy experience a decline in cognitive ability termed Cancer-Related Cognitive Impairment (CRCI). These impairments include difficulty with memory and attention, which may impact day-to-day life and work performance. Up to 35% of cancer patients continue to experience CRCI for months to years after treatment completion, suggesting a long-term cognitive deficiency. Developing quantitative methods to detect the neural correlates of CRCI, and treatments to mitigate its symptoms will be imperative to improve cancer patients' quality of life. However, such advances will require a better understanding of the neural mechanisms underlying CRCI. Studies of CRCI have demonstrated objective cognitive impairments on neuropsychological exams in patients following cancer treatment. The most frequently impaired cognitive domains include memory, executive functioning, processing speed, and attention. Chemotherapy, hormone therapy and other cancer treatments are thought to impair cognitive functioning by altering specific brain structures and/or impairing functional connectivity between brain regions. The hippocampus and prefrontal cortex (PFC) are known to be integrally involved in memory and executive functioning, and are particularly sensitive to the effects of such treatments. Moreover, structural and functional imaging studies suggest that adjuvant cancer therapies target the structure of brain hub regions within in resting state networks, as well as overall resting state connectivity integrity. Despite evidence of cognitive decline and structural and functional changes in cancer patients, the precise mechanism of impairment is poorly understood. The current collection of analysis revealed shape deformation on the surface of the hippocampus as well as decreases in cortical thickness in the left PFC. Bilateral hippocampal-cortical functional connectivity was increased in patients compared to controls. Increased hippocampal-precuneus functional connectivity was associated with worse perceived cognitive abilities. This work sheds light on possible neural compensation as well as biomarkers of self-reported cognitive concern in CRCI. |
| 590 | |
▼a School code: 0163. |
| 650 | 4 |
▼a Neurosciences. |
| 650 | 4 |
▼a Psychology. |
| 650 | 4 |
▼a Oncology. |
| 690 | |
▼a 0317 |
| 690 | |
▼a 0621 |
| 690 | |
▼a 0992 |
| 710 | 20 |
▼a Northwestern University.
▼b Clinical Psychology. |
| 773 | 0 |
▼t Dissertations Abstracts International
▼g 81-04B. |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0163 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2019 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15490272
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 202002
▼f 2020 |
| 990 | |
▼a ***1816162 |
| 991 | |
▼a E-BOOK |