| LDR | | 00000nam u2200205 4500 |
| 001 | | 000000436912 |
| 005 | | 20200228154018 |
| 008 | | 200131s2018 ||||||||||||||||| ||eng d |
| 020 | |
▼a 9781085559478 |
| 035 | |
▼a (MiAaPQ)AAI10823746 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 247004 |
| 082 | 0 |
▼a 615 |
| 100 | 1 |
▼a Kumar, Niyanta N. |
| 245 | 10 |
▼a Delivering Antibodies to the Brain: Distribution, Transport Mechanisms, and Dose-Response following Intranasal or Systemic Administration. |
| 260 | |
▼a [S.l.]:
▼b The University of Wisconsin - Madison.,
▼c 2018. |
| 260 | 1 |
▼a Ann Arbor:
▼b ProQuest Dissertations & Theses,
▼c 2018. |
| 300 | |
▼a 353 p. |
| 500 | |
▼a Source: Dissertations Abstracts International, Volume: 81-02, Section: B. |
| 500 | |
▼a Advisor: Thorne, Robert G. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018. |
| 506 | |
▼a This item must not be sold to any third party vendors. |
| 520 | |
▼a This work investigated the potential of intranasal delivery to rapidly and non-invasively target antibodies to the brain. Using complementary fluorescence and radiometric techniques, we demonstrated that full length immunoglobulin G (IgG) antibodies can access extracellular distribution pathways associated with the olfactory and trigeminal nerves to reach the olfactory bulbs and brainstem respectively, and the perivascular space (PVS) associated with cerebral blood vessels to subsequently distribute within the brain parenchyma. We also observed that for IgG doses resulting in similar blood levels following intranasal or intra-arterial delivery, the levels in the brain were significantly higher with intranasal administration. Overall, our findings suggest that intranasal application of IgG can rapidly achieve therapeutically relevant brain concentrations (mid picomolar to low nanomolar range) by accessing pathways that bypass the blood-brain barrier. We also found that protein size and receptor binding may affect the capacity of antibodies to access or exit the PVS. The brain soluble protein fraction following intranasal delivery of radiolabeled IgG yielded distinct heavy and light chain radiolabeled protein bands |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Pharmaceutical sciences. |
| 690 | |
▼a 0572 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Pharmaceutical Sciences. |
| 773 | 0 |
▼t Dissertations Abstracts International
▼g 81-02B. |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15490311
▼n KERIS
▼z 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
| 980 | |
▼a 202002
▼f 2020 |
| 990 | |
▼a ***1008102 |
| 991 | |
▼a E-BOOK |