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008220708s2022 mau ob 001 0 eng d
020 ▼a 9780262370028 ▼q (electronic bk.)
020 ▼a 0262370026 ▼q (electronic bk.)
020 ▼z 9780262046947
020 ▼z 0262046946
035 ▼a 3160177 ▼b (N$T)
035 ▼a (OCoLC)1334725183
037 ▼a 14366 ▼b MIT Press
037 ▼a 9780262370028 ▼b MIT Press
040 ▼a MITPR ▼b eng ▼e rda ▼e pn ▼c MITPR ▼d YDX ▼d EBLCP ▼d N$T ▼d 247004
050 4 ▼a R853.A53 ▼b S77 2022eb
08204 ▼a 616.02/7 ▼2 23/eng/20220708
1001 ▼a Striedter, Georg F., ▼d 1962- ▼e author.
24510 ▼a Model systems in biology : ▼b history, philosophy, and practical concerns/ ▼c Georg Striedter.
264 1 ▼a Cambridge, Massachusetts : ▼b The MIT Press, ▼c [2022]
300 ▼a 1 online resource (1 volume).
336 ▼a text ▼b txt ▼2 rdacontent
337 ▼a computer ▼b c ▼2 rdamedia
338 ▼a online resource ▼b cr ▼2 rdacarrier
504 ▼a Includes bibliographical references and index.
5050 ▼a Intro -- Contents -- Preface -- 1. Crises in Biomedical Research -- 1.1 The Translatability Crisis -- 1.2 The Replicability Crisis -- 1.3 Reckoning with Biological Variation -- 1.4 Which Model Is "Best"? -- 1.5 This Book's Approach and Organization -- 2. Philosophy of Models in Biology -- 2.1 Abstract Models -- 2.2 Material Models -- 2.3 Assumptions about Model Fidelity -- 2.4 Dealing with Biological Complexity -- 2.5 Animal Welfare and Cognitive Dissonance -- 2.6 Comparative Biology and August Krogh Revisited -- 3. A History of Animal Models -- 3.1 Eclectic Beginnings of Biology
5058 ▼a 3.2 Early Experimental Medicine: Research on Pet Species -- 3.3 Fruit Flies: The First Supermodel -- 3.4 Laboratory Rats: The First Standardized Mammals -- 3.5 Laboratory Mice: From Cancer Fighter to Model Organism -- 3.6 Nonhuman Primates -- 3.7 The Rest of the Menagerie -- 3.8 Model System Ecology -- 4. A History of in Vitro Models -- 4.1 Microbial Models -- 4.2 Cell and Tissue Culture Models -- 4.3 Alternative Models in Toxicology -- 4.4 Model Ecology Revisited -- 5. Models and Therapies: Infectious Diseases, Cardiovascular Disease, and Cancer -- 5.1 Infectious Diseases
5058 ▼a 5.2 Cardiovascular Diseases -- 5.3 Cancers -- 5.4 Patterns of Model Use -- 6. Neurological Disorders: Trials and Tribulations -- 6.1 Brain and Spinal Cord Injuries -- 6.2 Neurodegenerative Disorders -- 6.3 Neuropsychiatric Disorders -- 6.4 Successes, Failures, Hopes -- 7. Diagnosis and Recommendations -- 7.1 Four Perspectives on Models in Biology -- 7.2 Recommendations -- 7.3 Conclusion -- Appendix -- References -- Index
520 ▼a "Instead of arguing for a specific animal model, Striedter will review the history and philosophy of animal models in biomedical research, examining their various advantages and limitations"-- ▼c Provided by publisher.
5880 ▼a Print version record.
590 ▼a Added to collection customer.56279.3
650 0 ▼a Animal models in research.
650 0 ▼a Animal experimentation.
650 2 ▼a Animal Experimentation ▼0 (DNLM)D032761
650 6 ▼a Mode?les animaux dans la recherche. ▼0 (CaQQLa)201-0127335
650 6 ▼a Expe?rimentation animale. ▼0 (CaQQLa)201-0001372
650 7 ▼a Animal experimentation. ▼2 fast ▼0 (OCoLC)fst00809161
650 7 ▼a Animal models in research. ▼2 fast ▼0 (OCoLC)fst00809302
655 4 ▼a Electronic books.
77608 ▼i Print version: ▼a Striedter, Georg F., 1962- ▼t Model systems in biology. ▼d Cambridge, Massachusetts : The MIT Press, [2022] ▼z 9780262046947 ▼w (DLC) 2021033979 ▼w (OCoLC)1272882517
85640 ▼3 EBSCOhost ▼u https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=3160177
938 ▼a EBSCOhost ▼b EBSC ▼n 3160177
990 ▼a ***1818828
991 ▼a E-BOOK
994 ▼a 92 ▼b N$T