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Part I. the Rational Design, Synthesis, and Evaluation of Second Generation Class II HMG-COA Reductase Inhibitors Part II. Studies Directed Toward the On-Resin Preparation of C-Terminal Modified and Cyclic Peptides

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서명/저자사항Part I. the Rational Design, Synthesis, and Evaluation of Second Generation Class II HMG-COA Reductase Inhibitors Part II. Studies Directed Toward the On-Resin Preparation of C-Terminal Modified and Cyclic Peptides.
개인저자Hostetler, Matthew A.
단체저자명Purdue University. Chemistry.
발행사항[S.l.]: Purdue University., 2018.
발행사항Ann Arbor: ProQuest Dissertations & Theses, 2018.
형태사항381 p.
기본자료 저록Dissertation Abstracts International 80-01B(E).
Dissertation Abstract International
ISBN9780438361652
학위논문주기Thesis (Ph.D.)--Purdue University, 2018.
일반주기 Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Mark A. Lipton.
요약The first part of this dissertation involves the rational design, synthesis and biological evaluation of small molecules targeting Class II HMGR. Inhibitors of this generation were designed based on information derived from the crystal structure
요약The second part of this dissertation summarizes our efforts to contribute new methods for the preparation of C-terminal modified and cyclic peptides on the solid-phase using the backbone amide linker (BAL) approach. To this end, an improved one-
일반주제명Organic chemistry.
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