자료유형 | 학위논문 |
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서명/저자사항 | In vivo Vascular Imaging with Photoacoustic Microscopy. |
개인저자 | Hsu, Hsun-Chia. |
단체저자명 | Washington University in St. Louis. Biomedical Engineering. |
발행사항 | [S.l.]: Washington University in St. Louis., 2018. |
발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
형태사항 | 86 p. |
기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
ISBN | 9780438292338 |
학위논문주기 | Thesis (Ph.D.)--Washington University in St. Louis, 2018. |
일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Lihong V. Wang. |
요약 | Photoacoustic (PA) tomography (PAT) has received extensive attention in the last decade for its capability to provide label-free structural and functional imaging in biological tissue with highly scalable spatial resolution and penetration depth |
요약 | In this dissertation, one challenge was to quantitatively investigate red-blood-cell dynamics in nailfold capillaries with single-cell resolution PA microscopy (PAM). We recruited healthy volunteers and measured multiple hemodynamic parameters b |
요약 | We next conducted a pilot study on sickle cell disease (SCD), measuring and comparing the parameters related to RBC dynamics between healthy subjects and patients with SCD. In the patient group, we found that capillaries tended to be more tortuo |
요약 | As the last focus of this dissertation, we tackled the limited view problem in PAM by introducing an off-axis illumination technique for complementing the original detection view. We demonstrated this technique numerically and then experimentall |
일반주제명 | Medical imaging. Optics. Acoustics. |
언어 | 영어 |
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