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Molecular Pathways in Heart Development and Disease
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Molecular Pathways in Heart Development and Disease. |
| 개인저자 | Cho, Eunjin. |
| 단체저자명 | The University of Wisconsin - Madison. Molecular & Cellular Pharmacology. |
| 발행사항 | [S.l.]: The University of Wisconsin - Madison., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 164 p. |
| 기본자료 저록 | Dissertation Abstracts International 80-01B(E). Dissertation Abstract International |
| ISBN | 9780438367012 |
| 학위논문주기 | Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Youngsook Lee. |
| 요약 | Jarid2 (Jumonji A/T-rich interaction domain 2) is an essential factor for normal heart development. Deletion of Jarid2 in mice results in cardiac malformations recapitulating human congenital cardiac disease, and dysregulation of gene expression |
| 요약 | Interestingly, deletion of Jarid2 by alpha MHC-Cre (Jarid2alphaMHC) resulted in complete lethality by 9 months of age with dilated cardiomyopathy. Jarid2alphaMHC mice showed an increase in fetal gene expression, such as Tnni1 and Acta2 at neon |
| 요약 | These studies reveal the critical roles of Jarid2 in the myocardial development. Jarid2 is necessary to establish correct epigenetics on the target genomic loci during a narrow developmental window, which is prior to differentiation of cardiac p |
| 일반주제명 | Developmental biology. Biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
