자료유형 | 학위논문 |
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서명/저자사항 | Development of Biocatalytic Strategies for the Directed Oxidation of Small Molecule and Macrocyclic Substrates. |
개인저자 | Gilbert, Michael M. |
단체저자명 | University of Michigan. Chemistry. |
발행사항 | [S.l.]: University of Michigan., 2018. |
발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
형태사항 | 233 p. |
기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
ISBN | 9780438126855 |
학위논문주기 | Thesis (Ph.D.)--University of Michigan, 2018. |
일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: John Montgomery. |
요약 | The cytochrome P450 enzyme PikC has been explored as a robust biocatalyst for late-stage directed C-H hydroxylation reactions in organic synthesis. A collaborative effort between the Sherman, Houk, Podust, and Montgomery labs has resulted in the |
요약 | Previous studies had illustrated that unnatural substrates can be designed to enable the oxidation of inert C-H bonds. However, the ability to tune and reverse the regioselectivity of oxidations was not possible in prior efforts. This dissertati |
일반주제명 | Organic chemistry. Molecular chemistry. |
언어 | 영어 |
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