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Investigating the Effect of Peripheral Serotonin in Modulating High-Fat Diet Feeding in the Lactating Mammary Gland
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Investigating the Effect of Peripheral Serotonin in Modulating High-Fat Diet Feeding in the Lactating Mammary Gland. |
| 개인저자 | Cheng, Adrienne A. |
| 단체저자명 | The University of Wisconsin - Madison. Nutritional Sciences. |
| 발행사항 | [S.l.]: The University of Wisconsin - Madison., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 199 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-03B. Dissertation Abstract International |
| ISBN | 9781085725927 |
| 학위논문주기 | Thesis (Ph.D.)--The University of Wisconsin - Madison, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-03, Section: B.
Advisor: Hernandez, Laura L. |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | Obesity is a prevailing issue across the globe. Women who are obese often suffer from delayed onset of lactogenesis and tend to breastfeed for shorter durations. Breastfeeding is extremely important in infant development and has been demonstrated to decrease incidences type 2 diabetes and asthma later in life. Woefully, lactation is an understudied field and very little is known about the complexities of genotype, diet, and their subsequent lactation outcomes. Peripheral serotonin is becoming more well known as an anti-obesity target and is a large focus of this thesis. Additionally, we utilize the low-density lipoprotein receptor knockout (Ldlr-KO) mouse, as an exacerbated pro-obesity and hypercholesterolemic model. We also generated a Tph1/Ldlr KO (double knockout/DKO) model with the hopes of understanding how a pro-obesity and anti-obesity gene may interact. Chapter 2 demonstrates that during peak lactation, dams on a high-fat diet (HFD) have alterations in collagen biosynthesis, inflammation, and immune pathways. Additionally, consumption of a HFD altered mRNA splicing and isoform expression in the lactating mammary gland. Chapter 3 gives a cursory overview to how Tph1 responds to a LFD and HFD when in comparison to wildtype (WT) mice during peak lactation. Illustrated in Chapter 4 are the complexities between genotype and diet in relation to lactation. We characterize descriptive changes during early and mid-lactation, but it is not mechanistic in nature. Chapter 5 utilizes RNA-sequencing in order to get a better global overview of how varying genotypes have exclusive and interactive functions during lactation and demonstrates potential pathways of interest for us to explore in the future. Finally, chapter 6 utilizes a peripheral serotonin inhibitor during the peripartum period to emphasize the importance of conducting pharmacologic agents at all points in development and how inhibition does not necessarily mirror a transgenic mouse model. |
| 일반주제명 | Nutrition. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
