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The Efficacy of TDCS for Improving Gait in HD
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | The Efficacy of TDCS for Improving Gait in HD. |
| 개인저자 | Phipps, Alan M. |
| 단체저자명 | Indiana University. Health and Rehabilitation Sciences. |
| 발행사항 | [S.l.]: Indiana University., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 114 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-06B. Dissertation Abstract International |
| ISBN | 9781392781340 |
| 학위논문주기 | Thesis (Ph.D.)--Indiana University, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-06, Section: B.
Advisor: Koceja, David M |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | Huntington's disease (HD) is a rare neurogenerative disorder that results in the progressive loss of functional abilities, including motor function. Impaired motor function in HD is likely connected to a chain of events in the basal ganglia that results in the over-excitability of the motor cortex (M1). Of motor functions, gait is important to safely maneuver the environment. This poses a risk for HD patients as their gait exhibits several spatial and temporal abnormalities. The relative ease of accessing the motor cortex makes this area of the brain an attractive site for potential therapeutic noninvasive neurostimulation such as transcranial direct current stimulation (tDCS). tDCS has the ability to transiently modulate (increase or decrease) cortical excitability and has been shown to facilitate motor function in healthy subjects and patients with Parkinson's disease, another disorder of the basal ganglia. However, there is no literature available on the use of tDCS to modulate motor function or M1 excitability in HD. Therefore, the purpose of this study was to assess the feasibility of tDCS for modulating gait and cortical excitability in HD. This study was carried out in two experiments. Experiment 1 assessed the ability of tDCS for improving gait during treadmill walking (stride length, variability of stride length, step length symmetry, and the temporal reproducibility of the gait cycle), and Experiment 2 sought to expand on Experiment 1 with the addition of overground walking and TMS to assess M1 excitability. All subjects were able to complete the study. tDCS had variable effects on gait and cortical excitability in this population. This was a small study (n=4), and it may be of interest to explore noninvasive brain stimulation in population areas with a higher number of HD patients.David. |
| 일반주제명 | Kinesiology. Neurosciences. |
| 언어 | 영어 |
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