자료유형 | 학위논문 |
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서명/저자사항 | Extant Variation in the Maize Pan-Genome. |
개인저자 | Brohammer, Alex. |
단체저자명 | University of Minnesota. Applied Plant Sciences. |
발행사항 | [S.l.]: University of Minnesota., 2019. |
발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
형태사항 | 129 p. |
기본자료 저록 | Dissertations Abstracts International 81-02B. Dissertation Abstract International |
ISBN | 9781085565998 |
학위논문주기 | Thesis (Ph.D.)--University of Minnesota, 2019. |
일반주기 |
Source: Dissertations Abstracts International, Volume: 81-02, Section: B.
Advisor: Hirsch, Candice N. |
이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
요약 | The publication of the B73 maize reference genome assembly in 2009 was a monumental achievement and marked an important milestone in the field of maize genetics. This resource has been pivotal to countless discoveries since its release. One of the most surprising of these discoveries, however has been the finding that many sequences are missing or significantly diverged from the reference genome. This realization has helped spur the generation of alternative maize reference genome assemblies including one for the elite inbred line, PH207. The first chapter in this work provides a detailed historical perspective of the study of structural variation in maize and presents a review of the current understanding of the maize pan-genome. The middle chapter consists of original research using the PH207 reference genome to understand the significance of differential fractionation to the prevalence of structural variation in maize. The third chapter explores the contribution of transposable elements to variation in the maize transcriptome. Together these sections highlight the importance of using multiple maize reference genomes to understand the extraordinary diversity in the maize genome and point towards the need for a nuanced and contextualized understanding of this sequence diversity. |
일반주제명 | Plant sciences. Genetics. Bioinformatics. |
언어 | 영어 |
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