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Pharmacokinetics and toxicokinetics
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| 자료유형 | 단행본 |
|---|---|
| 서명/저자사항 | Pharmacokinetics and toxicokinetics/ Mehdi Boroujerdi. |
| 개인저자 | Boroujerdi, Mehdi,author. |
| 형태사항 | 1 online resource. |
| 기타형태 저록 | Print version: Boroujerdi, Mehdi. Pharmacokinetics and Toxicokinetics. Hoboken : CRC Press, ?015 9781482221343 |
| ISBN | 9781482221350 1482221357 |
| 서지주기 | Includes bibliographical references. |
| 내용주기 | Chapter 1. The influence of routes of administration on ADME -- chapter 2. Mechanisms of absorption and permeation of xenobiotics -- chapter 3. In Vivo distribution of xenobiotics -- chapter 4. Elimination rate, clearance, and the theoretical models -- chapter 5. Renal excretion of xenobiotics and estimation of related PK/TK parameters and constants -- chapter 6. Biotransformation of xenobiotics -- chapter 7. Kinetics of In Vitro metabolism : assimilation of intrinsic clearance in hepatic clearance -- chapter 8. Pharmaceutical, biopharmaceutical, and physiological factors influencing oral absorption : mechanistic absorption models -- chapter 9. Mathematical modeling in pharmacokinetics and toxicokinetics -- chapter 10. PK/TK analysis of instantaneous exposure to xenobiotics (single bolus injection) -- chapter 11. PK/TK analysis of continuous zero-order exposure to xenobiotics (intravenous infusion) -- chapter 12. PK/TK analysis of xenobiotics absorbed via an extravascular route of administration (oral administration) -- chapter 13. PK/TK of xenobiotics absorbed through the skin (transdermal absorption) -- chapter 14. PK/TK analysis of multiple dosing -- chapter 15. Bioavailability, bioequivalence, and biosimilar evaluations -- chapter 16. Preclinical PK/TK and clinical trials -- chapter 17. Population pharmacokinetics/toxicokinetics -- chapter 18. Quantitative extrapolation interspecies scaling/low dose extrapolation. |
| 요약 | The Influence of Routes of Administration on ADMEIntroductionPharmacokinetics (PK) and Pharmacodynamics (PD)Toxicokinetics (TK) and Toxicodynamics (TD)Concepts Basic to PK and TKInfluence of Routes of Exposure/Administration on PK/TK analysisBiomarkersReferencesMechanisms of Absorption and Permeation of XenobioticsIntroductionPassive DiffusionCarrier-Mediated Transcellular DiffusionTranscellular Diffusion Subject to P-Glycoprotein EffluxActive TransportEndocytosis and PinocytosisSolvent Drag, Osmosis, and Two-Pore TheoryIon-Pair AbsorptionReferencesIn Vivo Distribution of XenobioticsIntroducti. |
| 일반주제명 | Pharmacokinetics. Drugs --Toxicology. MEDICAL --Pharmacology. Drugs --Toxicology. Pharmacokinetics. |
| 언어 | 영어 |
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