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Animal models for microbiome research : advancing basic and translational science : proceedings of a workshop
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| 자료유형 | 단행본 |
|---|---|
| 서명/저자사항 | Animal models for microbiome research : advancing basic and translational science : proceedings of a workshop/ Joe Alper, Lida Anestidou, and Jenna Ogilvie, rapporteurs ; Roundtable on Science and Welfare in Laboratory Animal Use, Institute for Laboratory Animal Research, Division on Earth and Life Studies, National Academies of Sciences, Engineering, and Medicine. |
| 개인저자 | Alper, Joe,rapporteur. Ogilvie, Jenna,rapporteur, Anestidou, Lida,1965- rapporteur, |
| 단체저자명 | National Academies of Sciences, Engineering, and Medicine (U.S.). Division on Earth and Life Studies,issuing body. Institute for Laboratory Animal Research (U.S.). Roundtable on Science and Welfare in Laboratory Animal Use,issuing body. |
| 발행사항 | Washington, D.C.: National Academies Press, [2018]. |
| 형태사항 | 1 online resource (xv, 98 pages): illustrations (chiefly color). |
| 기타형태 저록 | Print version: Alper, Joe. Animal models for microbiome research. Washington, D.C. : National Academies Press, [2018] 9780309463881 |
| ISBN | 9780309463898 0309463890 |
| 기타표준부호 | 10.17226/24858doi |
| 서지주기 | Includes bibliographical references. |
| 내용주기 | Introduction -- A trans-kingdom perspective on animal models and microbiome research -- Non-rodent models for microbiome research -- Modeling human microbiota in animal systems -- Experimental reproducibility using gnotobiotic animal models -- Establishing and evolving gnotobiotic facilities -- Reflections on the workshop |
| 요약 | "The surface of the human body and its mucous membranes are heavily colonized by microorganisms. Our understanding of the contributions that complex microbial communities make to health and disease is advancing rapidly. Most microbiome research to date has focused on the mouse as a model organism for delineating the mechanisms that shape the assembly and dynamic operations of microbial communities. However, the mouse is not a perfect surrogate for studying different aspects of the microbiome and how it responds to various environmental and host stimuli, and as a result, researchers have been conducting microbiome studies in other animals. To examine the different animal models researchers employ in microbiome studies and to better understand the strengths and weaknesses of each of these model organisms as they relate to human and nonhuman health and disease, the Roundtable on Science and Welfare in Laboratory Animal Use of the National Academies of Sciences, Engineering, and Medicine convened a workshop in December 2016. The workshop participants explored how to improve the depth and breadth of analysis of microbial communities using various model organisms, the challenges of standardization and biological variability that are inherent in gnotobiotic animal-based research, the predictability and translatability of preclinical studies to humans, and strategies for expanding the infrastructure and tools for conducting studies in these types of models. This publication summarizes the presentations and discussions from the workshop"--Publisher's description. |
| 회의명 | Animal Models for Microbiome Research: Advancing Basic and Translational Science (Workshop) (2016 : Washington, D.C.), |
| 일반주제명 | Animal models in research --Congresses. Diseases --Animal models --Congresses. Microorganisms --Research --Congresses. Microbiota. Models, Animal. Disease Models, Animal. Metagenome. HEALTH & FITNESS / Diseases / General. MEDICAL / Clinical Medicine. MEDICAL / Diseases. MEDICAL / Evidence-Based Medicine. MEDICAL / Internal Medicine. |
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