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Using 21st century science to improve risk-related evaluations
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| 자료유형 | 단행본 |
|---|---|
| 서명/저자사항 | Using 21st century science to improve risk-related evaluations/ Committee on Incorporating 21st Century Science into Risk-Based Evaluations, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies ; a report of the National Academies of Sciences, Engineering, Medicine. |
| 단체저자명 | National Academies of Sciences, Engineering, and Medicine (U.S.). Committee on Incorporating 21st Century Science into Risk-Based Evaluations. |
| 발행사항 | Washington, DC: The National Academies Press, [2017]. |
| 형태사항 | 1 online resource (xviii, 182 pages): color illustrations. |
| 기타형태 저록 | Print version: National Academies of Sciences, Engineering, and Medicine (U.S.). Committee on Incorporating 21st Century Science into Risk-Based Evaluations. Using 21st century science to improve risk-related evaluations. Washington, DC : The National Academies Press, [2017] 0309453488 9780309453486 |
| ISBN | 9780309453493 0309453496 |
| 서지주기 | Includes bibliographical references. |
| 내용주기 | Introduction -- Advances in exposure science -- Advances in toxicology -- Advances in epidemiology -- A new direction for risk assessment and applications of 21st century science -- Model and assay validation and acceptance -- Interpretation and integration of data and evidence for risk-based decision-making -- Appendix A: Biographical information on the Committee on Incorporating 21st century Science into Risk-Based Evaluations -- Appendix B: Case studies on chemical assessments -- Appendix C: Case studies on site-specific assessments -- Appendix D: Case study on assessment of new chemistry -- Appendix E: A Bayesian Example: predicting dose response relationships from high-throughput data and chemical structure. |
| 요약 | "Over the last decade, several large-scale United States and international programs have been initiated to incorporate advances in molecular and cellular biology, -omics technologies, analytical methods, bioinformatics, and computational tools and methods into the field of toxicology. Similar efforts are being pursued in the field of exposure science with the goals of obtaining more accurate and complete exposure data on individuals and populations for thousands of chemicals over the lifespan; predicting exposures from use data and chemical-property information; and translating exposures between test systems and humans. Using 21st Century Science to Improve Risk-Related Evaluations makes recommendations for integrating new scientific approaches into risk-based evaluations. This study considers the scientific advances that have occurred following the publication of the NRC reports Toxicity Testing in the 21st Century: A Vision and a Strategy and Exposure Science in the 21st Century: A Vision and a Strategy. Given the various ongoing lines of investigation and new data streams that have emerged, this publication proposes how best to integrate and use the emerging results in evaluating chemical risk. Using 21st Century Science to Improve Risk-Related Evaluations considers whether a new paradigm is needed for data validation, how to integrate the divergent data streams, how uncertainty might need to be characterized, and how best to communicate the new approaches so that they are understandable to various stakeholders"--Publisher's description. |
| 일반주제명 | Environmental toxicology --Risk assessment --Evaluation. Science --Risk assessment --Evaluation. MEDICAL --Toxicology. MEDICAL --Pharmacology. |
| 언어 | 영어 |
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