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Polymeric Nanoparticles and Microparticles for the Delivery of Hydrophobic and Hydrophilic Therapeutics
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Polymeric Nanoparticles and Microparticles for the Delivery of Hydrophobic and Hydrophilic Therapeutics. |
| 개인저자 | Pagels, Robert F. |
| 단체저자명 | Princeton University. Chemical and Biological Engineering. |
| 발행사항 | [S.l.]: Princeton University., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 405 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-10B(E). Dissertation Abstract International |
| ISBN | 9780438048652 |
| 학위논문주기 | Thesis (Ph.D.)--Princeton University, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Robert K. Prud'homme. |
| 이용제한사항 | This item is not available from ProQuest Dissertations & Theses. |
| 요약 | Polymeric particle formulations can improve the therapeutic performance of two distinct drug classes: hydrophobic small molecules and hydrophilic biologic macromolecules. Nanoparticle formulations of hydrophobic drugs can increase the dissolutio |
| 요약 | The work presented herein applies the Flash NanoPrecipitation (FNP) process to the formulation of both water-insoluble (Part I) and water-soluble (Part II) materials. FNP has traditionally been used to produce nanoparticles of hydrophobic therap |
| 요약 | In Part II, the FNP process was inverted (iFNP) to allow for the encapsulation of hydrophilic molecules. The new iFNP process was demonstrated on a variety of model drugs, and the methods to control nanoparticle size were established. The result |
| 요약 | In summary, this dissertation expands the applicability of the FNP platform technology, enabling new nanoparticle and microparticle formulations of therapeutics. |
| 일반주제명 | Chemical engineering. Nanoscience. Polymer chemistry. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
