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LYN Regulates Drug Resistance Mechanisms in Chronic Myelogenous Leukemia (CML)
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | LYN Regulates Drug Resistance Mechanisms in Chronic Myelogenous Leukemia (CML). |
| 개인저자 | Okumu, Denis O. |
| 단체저자명 | The University of North Carolina at Chapel Hill. Pharmacology. |
| 발행사항 | [S.l.]: The University of North Carolina at Chapel Hill., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 135 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-10B(E). Dissertation Abstract International |
| ISBN | 9780438065741 |
| 학위논문주기 | Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisers: Lee M. Graves |
| 요약 | Acquired resistance to anti-cancer therapy presents a critical challenge to effective clinical management of chronic myelogenous leukemia (CML). Drug-resistant CML cells devise diverse molecular adaptations to evade therapy. Examples of such ada |
| 요약 | In the first project, I showed that increased Lyn expression and activity in Myl-R cells up-regulated the expression and stability of BIRC6, a member of the inhibitor of apoptosis proteins (IAP) family known to bind and inactivate active caspase |
| 요약 | In the second project, I am investigating Lyn's role in regulating creatine uptake by Myl-R cells. Our lab previously showed that total intracellular creatine pool was 5-fold higher in Myl-R than Myl cells. Our unpublished data show that the inc |
| 요약 | Taken together, these studies enrich our understanding of the diverse therapy-survival mechanisms utilized by CML cells, and provide insights into novel targets for effective cure of CML. |
| 일반주제명 | Pharmacology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
