상세정보
Export to Refworks부가기능
Mechanical Regulation of Genomic Instability in Cancer
상세 프로파일
| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Mechanical Regulation of Genomic Instability in Cancer. |
| 개인저자 | Simi, Allison K. |
| 단체저자명 | Princeton University. Chemical and Biological Engineering. |
| 발행사항 | [S.l.]: Princeton University., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 127 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-10B(E). Dissertation Abstract International |
| ISBN | 9780438050563 |
| 학위논문주기 | Thesis (Ph.D.)--Princeton University, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Celeste M. Nelson. |
| 요약 | It is expected that 1 in 3 people in the United States will develop cancer in their lifetime, and it remains the second leading cause of death worldwide. The research that drove most current cancer therapies focused primarily on the cancer cells |
| 요약 | We found that increased stiffness induces multinucleation, regulated in part by signaling downstream of matrix metalloproteinase-3 (MMP 3). MMP3 is commonly upregulated in cancer and known to induce epithelial-mesenchymal transition (EMT), a pro |
| 요약 | Following these findings, we investigated the specific mechanisms by which stiffness and EMT signaling induce multinucleation. We found that elevated levels of septin-6, a novel target of Snail, results in midbody persistence, abscission failure |
| 요약 | Taken together, these data suggest that tissue stiffening during tumorigenesis synergizes with oncogenic signaling to promote genomic abnormalities that drive cancer progression, and provide the first evidence that mechanical stiffness of the mi |
| 일반주제명 | Bioengineering. Oncology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
