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Mechanistic Evaluation of Polyethylene Oxide for Physical Barrier Type Abuse Deterrent Formulations: Techniques and In Vitro Methods
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Mechanistic Evaluation of Polyethylene Oxide for Physical Barrier Type Abuse Deterrent Formulations: Techniques and In Vitro Methods. |
| 개인저자 | Boyce, Heather J. |
| 단체저자명 | University of Maryland, Baltimore. Pharmaceutical Sciences. |
| 발행사항 | [S.l.]: University of Maryland, Baltimore., 2017. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2017. |
| 형태사항 | 256 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-05B(E). Dissertation Abstract International |
| ISBN | 9780355591095 |
| 학위논문주기 | Thesis (Ph.D.)--University of Maryland, Baltimore, 2017. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-05(E), Section: B.
Adviser: Stephen W. Hoag. |
| 이용제한사항 | This item is not available from ProQuest Dissertations & Theses. |
| 요약 | Abuse deterrent formulations (ADF) are designed to mitigate misuse and abuse of prescription narcotics. One mechanism of an ADF is to increase the tablet strength to reduce ease of tablet comminution while increasing the difficulty of drug extra |
| 요약 | Key results of this study show that heating tablets with PEO will significantly increase the strength of the tablet and key variables such as PEO composition, particle size distribution, high initial tablet solid fraction, and 1 h sinter time we |
| 요약 | Finally, the in vitro nasal insufflation studies demonstrated that for each type of physical manipulation employed (i.e. cutting, grinding, milling), discreet particle size distributions were formed regardless of formulation. One exception occur |
| 일반주제명 | Pharmaceutical sciences. |
| 언어 | 영어 |
| 바로가기 | 
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