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Analyzing Heterogeneity in Neuroimaging with Probabilistic Multivariate Clustering Approaches

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서명/저자사항Analyzing Heterogeneity in Neuroimaging with Probabilistic Multivariate Clustering Approaches.
개인저자Dong, Aoyan.
단체저자명University of Pennsylvania. Electrical and Systems Engineering.
발행사항[S.l.]: University of Pennsylvania., 2017.
발행사항Ann Arbor: ProQuest Dissertations & Theses, 2017.
형태사항143 p.
기본자료 저록Dissertation Abstracts International 79-07B(E).
Dissertation Abstract International
ISBN9780355618440
학위논문주기Thesis (Ph.D.)--University of Pennsylvania, 2017.
일반주기 Source: Dissertation Abstracts International, Volume: 79-07(E), Section: B.
Adviser: Christos Davatzikos.
이용제한사항This item is not available from ProQuest Dissertations & Theses.
요약Automated quantitative neuroimaging analysis methods have been crucial in elucidating normal and pathological brain structure and function, and in building in vivo markers of disease and its progression. Commonly used methods can identify and pr
요약In this thesis, we leveraged machine learning techniques to develop novel tools that can analyze the heterogeneity in both cross-sectional and longitudinal neuroimaging studies. Specifically, we developed a semi-supervised clustering method for
요약The proposed tools were extensively validated using synthetic data. Importantly, they were applied to study the heterogeneity in large clinical neuroimaging cohorts. We identified four disease subtypes with distinct imaging signatures using data
일반주제명Electrical engineering.
Medical imaging.
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