상세정보
Export to Refworks부가기능
Merkel Cell Carcinoma: Immunogenicity and the Characterization of CD4 T Cell Responses to the Merkel Cell Polyomavirus
상세 프로파일
| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Merkel Cell Carcinoma: Immunogenicity and the Characterization of CD4 T Cell Responses to the Merkel Cell Polyomavirus. |
| 개인저자 | Vandeven, Natalie A. |
| 단체저자명 | University of Washington. Pathology. |
| 발행사항 | [S.l.]: University of Washington., 2017. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2017. |
| 형태사항 | 194 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-05B(E). Dissertation Abstract International |
| ISBN | 9780355595222 |
| 학위논문주기 | Thesis (Ph.D.)--University of Washington, 2017. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-05(E), Section: B.
Adviser: Paul Nghiem. |
| 이용제한사항 | This item is not available from ProQuest Dissertations & Theses. |
| 요약 | Merkel cell carcinoma (MCC) is a deadly, virus-associated skin cancer with a 5-year relative mortality rate of 46%. The Merkel cell polyomavirus (MCPyV) is clonally integrated into 80% of MCCs and persistent expression of MCPyV T-antigen oncopro |
| 요약 | Within the opening chapters, we explore pathogen-driven cancers more broadly (Chapter 1) before delving specifically into MCPyV-induced MCC, its rising incidence rate (Chapter 2) and known mechanisms of immune evasion (Chapter 3). Previous studi |
| 요약 | This past year (2017) historically marked the first FDA approval of an agent for the treatment of advanced MCC. Therefore, as we continue to treat more MCC patients with this agent (avelumab |
| 일반주제명 | Oncology. Immunology. Pathology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
