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Molecular Insight into the Structure, Function, and Regulation of Bile Acid Transport
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Molecular Insight into the Structure, Function, and Regulation of Bile Acid Transport. |
| 개인저자 | Czuba, Lindsay Christine. |
| 단체저자명 | University of Maryland, Baltimore. Pharmaceutical Sciences. |
| 발행사항 | [S.l.]: University of Maryland, Baltimore., 2017. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2017. |
| 형태사항 | 183 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-05B(E). Dissertation Abstract International |
| ISBN | 9780355591248 |
| 학위논문주기 | Thesis (Ph.D.)--University of Maryland, Baltimore, 2017. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-05(E), Section: B.
Adviser: Peter W. Swaan. |
| 이용제한사항 | This item is not available from ProQuest Dissertations & Theses. |
| 요약 | The human Apical Sodium-dependent Bile Acid Transporter (SLC10A2), also known as hASBT, plays an integral role in the enterohepatic circulation of bile acid and cholesterol homeostasis. As a member of the solute carrier family of membrane transp |
| 요약 | Limiting the development of such therapeutics, is an incomplete understanding of hASBT's structure. Extensive biochemical and mutagenesis studies for hASBT support a seven transmembrane model. Yet conflicting structures have emerged with the elu |
| 요약 | In this work we provide novel molecular insight into the structure, function, and regulation of human ASBT. We contrasted the biochemical, inhibitory, and evolutionary attributes of nmAsbt, yfAsbt, and hASBT and identified their critical differe |
| 요약 | Additionally, we characterized the role of tyrosine phosphorylation in regulating the functional expression and stability of hASBT. We identified Src family kinases as critical modulators and provide support for hASBT's regulation by phosphatase |
| 요약 | Finally, we have optimized the biological sample preparation methods and have significantly increased the purity of hASBT samples. When coupled with mass spectrometry analysis, these methods will identify critical proteoforms of hASBT and facili |
| 일반주제명 | Pharmaceutical sciences. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
