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Computational Studies of Lipid Bilayers and Transmembrane Proteins

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자료유형학위논문
서명/저자사항Computational Studies of Lipid Bilayers and Transmembrane Proteins.
개인저자Khakbaz, Pouyan.
단체저자명University of Maryland, College Park. Chemical Engineering.
발행사항[S.l.]: University of Maryland, College Park., 2018.
발행사항Ann Arbor: ProQuest Dissertations & Theses, 2018.
형태사항150 p.
기본자료 저록Dissertation Abstracts International 79-11B(E).
Dissertation Abstract International
ISBN9780438139886
학위논문주기Thesis (Ph.D.)--University of Maryland, College Park, 2018.
일반주기 Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Adviser: Jeffery B. Klauda.
요약Deep understanding of lipid bilayers in three phases at the molecular level could potentially lead us to design a novel artificial membrane. Molecular modeling of bacterial membranes is important as they are cheap and an environmentally friendly
요약The inner membrane of Escherichia coli (E. coli) was modeled to include lipid diversity and demonstrate that this is needed to properly probe the interaction of lipids and transmembrane proteins. Molecular dynamics (MD) simulations were used wit
요약Phase transitions of fully saturated lipid bilayers, 1,2-dimyristoyl- sn-glycero-3-phosphocholine (DMPC) and 1,2-dipalmitoyl-sn -glycero-phosphocholine (DPPC) and their mixtures were probed for the first time using MD simulations. The phase tran
요약The final two topics involved collaborations with experimental labs to provide insight into experimental observables. First, MD simulations successfully showed that improved tolerance and production of biorenewables of a metabolically engineered
일반주제명Biophysics.
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