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Understanding (p)ppGpp-mediated Mechanisms of Persistence and Stress Survival in Bacillus subtilis
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Understanding (p)ppGpp-mediated Mechanisms of Persistence and Stress Survival in Bacillus subtilis. |
| 개인저자 | Barra, Jessica Tse. |
| 단체저자명 | The University of Wisconsin - Madison. Microbiology ALS. |
| 발행사항 | [S.l.]: The University of Wisconsin - Madison., 2017. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2017. |
| 형태사항 | 261 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-11B(E). Dissertation Abstract International |
| ISBN | 9780438159679 |
| 학위논문주기 | Thesis (Ph.D.)--The University of Wisconsin - Madison, 2017. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Adviser: Jue D. Wang. |
| 요약 | During amino acid starvation, the Gram-positive bacterium Bacillus subtilis, produces a molecule called (p)ppGpp, a nucleotide derived from GTP or GDP and ATP. This molecule is produced by almost all bacteria but its effects are best characteriz |
| 요약 | We examined the role of (p)ppGpp in mediating persistence, the ability of a subpopulation of bacteria to survive antibiotics for a prolonged period of time. We demonstrate that (p)ppGpp is one mechanism of persister formation and is necessary an |
| 요약 | (p)ppGpp and GTP-dependent mechanisms protect cells against bacteriostatic antibiotics. We treated wild type and (p)ppGpp0 cells with chloramphenicol and saw that (p)ppGpp0 cells lose viability. Interestingly, RelA was the primary (p)ppGpp synth |
| 요약 | In this work, we comprehensively examined the role of (p)ppGpp in mediating stress survival in persistence. |
| 일반주제명 | Microbiology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
