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Longitudinal Cerebrospinal Fluid Biomarkers of Alzheimer Disease: Movement Toward the Diagnosis, Prognosis and Staging of Disease
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Longitudinal Cerebrospinal Fluid Biomarkers of Alzheimer Disease: Movement Toward the Diagnosis, Prognosis and Staging of Disease. |
| 개인저자 | Sutphen, Courtney. |
| 단체저자명 | Washington University in St. Louis. Biology & Biomedical Sciences (Neurosciences). |
| 발행사항 | [S.l.]: Washington University in St. Louis., 2017. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2017. |
| 형태사항 | 194 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-05B(E). Dissertation Abstract International |
| ISBN | 9780355555387 |
| 학위논문주기 | Thesis (Ph.D.)--Washington University in St. Louis, 2017. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-05(E), Section: B.
Advisers: Anne M. Fagan |
| 이용제한사항 | This item is not available from ProQuest Dissertations & Theses. |
| 요약 | Alzheimer's disease (AD) is a devastating neurodegenerative disease that slowly claims the memories and experiences that comprise the life experiences of individuals that suffer from the disease. Despite a continually accelerating pace of resear |
| 요약 | One important aspect of AD treatment is identification. It is now recognized that the disease begins more than a decade before the signature symptoms of cognitive impairment become apparent. Identifying individuals in this "preclinical" disease |
| 요약 | Biomarkers, indicators of normal biological or pathological processes that may be studied as a means to give individuals a disease diagnosis, prognosis, or theragnosis -- provided a treatment is available for the disease in question -- are of pa |
| 요약 | The current work begins with an overview of biomarker modalities used in AD |
| 요약 | The ACS cohort is comprised of middle-aged, cognitively normal individuals recruited on a volunteer basis from community dwelling participants with and without a family history of AD. The ADNI cohort is comprised of older individuals also recrui |
| 요약 | In both cohorts, it was found that CSF markers of amyloid plaques -- one of two required pathological hallmarks that indicate AD -- changed earlier than those of tau tangles, the second required pathological hallmark. |
| 요약 | Currently, examining biomarkers on a group-wide basis is the best way to get an accurate picture of biomarkers at baseline and followup lumbar punctures (LPs). As the goal is to be able to give individual people a diagnosis and prognosis of thei |
| 일반주제명 | Neurosciences. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
