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Efficient and Scalable Markov Chain Monte Carlo Methods and Its Biological Applications

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자료유형학위논문
서명/저자사항Efficient and Scalable Markov Chain Monte Carlo Methods and Its Biological Applications.
개인저자Zhang, Yizhe.
단체저자명Duke University. Computational Biology and Bioinformatics.
발행사항[S.l.]: Duke University., 2018.
발행사항Ann Arbor: ProQuest Dissertations & Theses, 2018.
형태사항169 p.
기본자료 저록Dissertation Abstracts International 79-09B(E).
Dissertation Abstract International
ISBN9780355872736
학위논문주기Thesis (Ph.D.)--Duke University, 2018.
일반주기 Source: Dissertation Abstracts International, Volume: 79-09(E), Section: B.
Adviser: Lawerence Carin.
이용제한사항This item is not available from ProQuest Dissertations & Theses.
요약Markov Chain Monte Carlo (MCMC) stands as a fundamental approach for probabilistic inference in many computational statistics problems. Its application to computational biology and bioinformatics has attracted much attention in recent decades. A
요약This thesis first focus on the theoretical connection (chapter 3), the unification and generalization of slice sampling and HMC. Base on these theoretical analysis, I present a generalized HMC that demonstrate efficient exploration of target dis
요약The second part of the thesis, presented in chapter 4, concerns some advances remedying the practical issues of the generalized sampler, and how to scale up with large datasets. Chapter 4 first develops a novel scalable approximate sampling appr
요약The remaining part of this thesis, consisting chapter 5 and chapter 6, discuss advances of scalable Bayesian method for some generic and core Biomedical applications. Two Bayesian inferential tasks involving latent variable model are discussed.
요약Finally, chapter 7 concludes the dissertation and discussion some potential future studies in both methodology and applications.
일반주제명Statistics.
Bioinformatics.
Computer science.
언어영어
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