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Application of Advances in Synthetic Biology to Modular Megasynthase Design and Scalable Combinatorial Biosynthesis
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Application of Advances in Synthetic Biology to Modular Megasynthase Design and Scalable Combinatorial Biosynthesis. |
| 개인저자 | Grau, William Clifford. |
| 단체저자명 | University of Colorado at Boulder. Chemistry. |
| 발행사항 | [S.l.]: University of Colorado at Boulder., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 188 p. |
| 기본자료 저록 | Dissertation Abstracts International 80-02B(E). Dissertation Abstract International |
| ISBN | 9780438383920 |
| 학위논문주기 | Thesis (Ph.D.)--University of Colorado at Boulder, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B.
Adviser: Ryan T. Gill. |
| 요약 | The diversity in structure and biological activity of natural products has long captured the imagination of chemists and molecular biologists alike. Natural products are synthesized by elaborate secondary metabolic pathways or enzymes. For examp |
| 요약 | Prior efforts to rationally design modular megasynthases have demonstrated some success but combinatorial forward engineering remains unfulfilled. The rise of synthetic biology has presented new capabilities to resolve the underlying deficiencie |
| 요약 | Herein, we present a precise and scalable synthetic biology approach to combinatorial biosynthesis built on improved abstraction of modular megasynthases into 'parts'. The approach begins with bottom-up design of a chimeric modular megasynthase |
| 요약 | To demonstrate this approach, we first targeted the production of a triketide lactone food and fragrance ingredient, d-hexalactone. A retrosynthetic analysis identified catalytic domains, linkers, and substrates required for d-hexalactone biosyn |
| 일반주제명 | Chemistry. Bioengineering. Chemical engineering. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
