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Interrogating the Functional Consequences of Peripheral Neuropathy Associated Mutations in Heat Shock Protein B1
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Interrogating the Functional Consequences of Peripheral Neuropathy Associated Mutations in Heat Shock Protein B1. |
| 개인저자 | Heilman, Patrick Lawrence. |
| 단체저자명 | The Ohio State University. Biochemistry. |
| 발행사항 | [S.l.]: The Ohio State University., 2017. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2017. |
| 형태사항 | 173 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438098022 |
| 학위논문주기 | Thesis (Ph.D.)--The Ohio State University, 2017. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Stephen Kolb. |
| 요약 | Heat shock protein beta-1 (HSPB1), is a ubiquitously expressed, multifunctional protein chaperone that plays an important role in protein quality control, inflammation, apoptosis, cell growth and cytoskeleton maintenance. Mutations in HSPB1 resu |
| 요약 | To elucidate a mechanism of HSPB1-mediated neuroprotection, I examined the role of wild-type and mutant HSPB1 in regulating inflammatory gene expression through activation of NF-kB signaling and mRNA decay apthways. Wild-type, but not mutant HSP |
| 일반주제명 | Biochemistry. Neurosciences. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
