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Synthetic Study of Amphidinolides C, C2, C3, and F: Construction of the C1--C9 and the C10--C25 Building Blocks

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서명/저자사항Synthetic Study of Amphidinolides C, C2, C3, and F: Construction of the C1--C9 and the C10--C25 Building Blocks.
개인저자Akwaboah, Daniel Clement.
단체저자명The Ohio State University. Chemistry.
발행사항[S.l.]: The Ohio State University., 2017.
발행사항Ann Arbor: ProQuest Dissertations & Theses, 2017.
형태사항333 p.
기본자료 저록Dissertation Abstracts International 79-12B(E).
Dissertation Abstract International
ISBN9780438098381
학위논문주기Thesis (Ph.D.)--The Ohio State University, 2017.
일반주기 Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Craig Forsyth.
요약Amphidinolides C, C2, C3, and F are cytotoxic secondary metabolites that occur naturally from symbiotic marine dinoflagellates Amphidinium sp. from the Okinawan flatworm. They share an identical 25-membered macrolide core that possesses 11 ster
요약Our contribution to the amphidinolide project was designed to assemble a common macrolide framework which could be elaborated with minimal synthetic manipulations to access all four target molecules. We recognized a hidden structural homology th
일반주제명Chemistry.
Organic chemistry.
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