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Influenza Virus Evolution within and Between Human Hosts
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Influenza Virus Evolution within and Between Human Hosts. |
| 개인저자 | McCrone, John T., IV. |
| 단체저자명 | University of Michigan. Microbiology & Immunology. |
| 발행사항 | [S.l.]: University of Michigan., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 173 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438126060 |
| 학위논문주기 | Thesis (Ph.D.)--University of Michigan, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Adam Lauring. |
| 요약 | Rapid adaptive evolution significantly contributes to the size and severity of seasonal influenza epidemics. While influenza evolution has been well defined at the global scale, these dynamics ultimately derive from processes that take place wit |
| 요약 | In my thesis, I have applied an empirically-validated, next-generation sequencing approach to over 300 patient-derived samples from two vaccinated cohorts to define influenza evolution within and between naturally infected individuals. I compare |
| 요약 | In the second study, I used quantitative models to define influenza virus dynamics in individuals enrolled in a prospective, community-based cohort. Sequence data from 35 serially sampled individuals suggested that within-host populations are dy |
| 요약 | These data suggest that contrary to the global dynamics, positive selection is inefficient at the level of the individual host. Genetic drift and other stochastic processes likely dominate the host-level evolution of influenza viruses. |
| 일반주제명 | Virology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
