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Investigation of Membrane Order within Integrin-Mediated Adhesion
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Investigation of Membrane Order within Integrin-Mediated Adhesion. |
| 개인저자 | Bourg, Julia Tofalo. |
| 단체저자명 | University of Michigan. Biophysics. |
| 발행사항 | [S.l.]: University of Michigan., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 108 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438127029 |
| 학위논문주기 | Thesis (Ph.D.)--University of Michigan, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Sarah Veatch. |
| 요약 | Integrins are transmembrane adhesion receptors that engage ligands in the extracellular matrix and cytoskeletal proteins to form multi-protein adhesive complexes. These complexes provide a platform for integrin signaling and a mechanical anchor |
| 요약 | This dissertation investigates how integrins associate with membrane order through newly developed super-resolution imaging techniques that are capable of directly observing the local enrichment and depletion of peptide markers of liquid-ordered |
| 요약 | I find that beta1 integrins co-localize with both markers of membrane order and disorder across the plasma membrane. I find that affinity for a membrane ordered probe depends on activation state and that beta1 integrins from mature fibrillar adh |
| 요약 | The structure-function relationship of integrins has broad biological implications contributing to cell viability, growth, and motility. My work indicates that integrin association with membrane order is more subtle than previously proposed and |
| 일반주제명 | Biophysics. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
