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Investigation of Protein-RNA Interactions of the TAR-RNA Binding Protein (TRBP)
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Investigation of Protein-RNA Interactions of the TAR-RNA Binding Protein (TRBP). |
| 개인저자 | Acevedo, Roderico. |
| 단체저자명 | The Pennsylvania State University. Chemistry. |
| 발행사항 | [S.l.]: The Pennsylvania State University., 2016. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2016. |
| 형태사항 | 207 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438134348 |
| 학위논문주기 | Thesis (Ph.D.)--The Pennsylvania State University, 2016. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
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| 요약 | Post-transcriptional regulation of gene expression is dependent on multiple RNA silencing pathways, termed generally as RNA interference (RNAi). Silencing occurs through use of single-stranded RNAs, produced as double-stranded precursors, in two |
| 요약 | TRBP contains 3 double-stranded RNA binding domains (dsRBDs). Here, we focus on the first two dsRBDs, which have been shown to bind dsRNA. By monitoring the binding affinity of the first two dsRBDs of TRBP individually (TRBP-dsRBD1 and TRBP-dsRB |
| 요약 | Further inspection of TRBP-DeltaC's binding thermodynamics using isothermal titration calorimetry revealed that changing the linker length between dsRBDs modulates TRBP-DeltaC binding affinity. Jacobson-Stockmayer analysis of the linker length d |
| 일반주제명 | Chemistry. Biochemistry. Biophysics. |
| 언어 | 영어 |
| 바로가기 | 
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