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Complement and Antibody-Mediated Enhancement of Red Blood Cell Invasion by Plasmodium Falciparum
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Complement and Antibody-Mediated Enhancement of Red Blood Cell Invasion by Plasmodium Falciparum. |
| 개인저자 | Biryukov, Sergei Sergeievich. |
| 단체저자명 | The Pennsylvania State University. Microbiology and Immunology. |
| 발행사항 | [S.l.]: The Pennsylvania State University., 2016. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2016. |
| 형태사항 | 215 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438134508 |
| 학위논문주기 | Thesis (Ph.D.)--The Pennsylvania State University, 2016. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
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| 요약 | Plasmodium falciparum malaria is responsible for close to one million deaths worldwide each year. The Plasmodium life cycle involves invasion of hepatocytes and erythrocytes. The repeating cycle of erythrocyte invasion and destruction is the roo |
| 요약 | We hypothesize that complement activation and opsonization of merozoites enhances complement receptor 1 (CR1)-mediated invasion of erythrocytes. If we are correct, the parasite can hijack this arm of the innate immune response for its own benefi |
| 요약 | In addition, we utilized erythrocytes from individuals with paroxysmal nocturnal hemoglobinuria (PNH), which results in the absence of glycosylphosphatidylinositol (GPI)-anchored receptors, in an effort to identify novel receptors utilized by th |
| 요약 | Our results demonstrate that merozoites can highjack the complement system to their own advantage in a number of ways. Activation of the complement cascade via the classical pathway can allow merozoites to bind to CR1 and invade via this pathway |
| 일반주제명 | Microbiology. Immunology. Parasitology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
