자료유형 | 학위논문 |
---|---|
서명/저자사항 | The Role of D52 in Acinar Homeostasis. |
개인저자 | Jones, Elaina K. |
단체저자명 | The University of Wisconsin - Madison. Nutritional Sciences. |
발행사항 | [S.l.]: The University of Wisconsin - Madison., 2018. |
발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
형태사항 | 123 p. |
기본자료 저록 | Dissertation Abstracts International 79-11B(E). Dissertation Abstract International |
ISBN | 9780438115552 |
학위논문주기 | Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018. |
일반주기 |
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Adviser: Guy E. Groblewski. |
요약 | D52 is a cytosolic, peripheral membrane associated protein that binds a number of membrane trafficking associated proteins and is highly expressed in pancreatic acinar cells. Work by the Groblewski lab has identified a role for D52 in regulating |
요약 | Pancreatitis induces acinar cell dedifferentiation to a duct-like exocrine progenitor state as a mechanism of recovery. The dedifferentiated progenitors proliferate to repopulate the gland before differentiating back into acinar cells under the |
요약 | In Chapter four, we utilized an inducible model of acinar specific D52 deletion (D52--/--) to investigate the impact of losing D52 expression, an early event in the onset of pancreatitis. Loss of D52 alone caused significant acinar cell damage, |
일반주제명 | Cellular biology. |
언어 | 영어 |
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