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The Role of D52 in Acinar Homeostasis
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | The Role of D52 in Acinar Homeostasis. |
| 개인저자 | Jones, Elaina K. |
| 단체저자명 | The University of Wisconsin - Madison. Nutritional Sciences. |
| 발행사항 | [S.l.]: The University of Wisconsin - Madison., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 123 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-11B(E). Dissertation Abstract International |
| ISBN | 9780438115552 |
| 학위논문주기 | Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Adviser: Guy E. Groblewski. |
| 요약 | D52 is a cytosolic, peripheral membrane associated protein that binds a number of membrane trafficking associated proteins and is highly expressed in pancreatic acinar cells. Work by the Groblewski lab has identified a role for D52 in regulating |
| 요약 | Pancreatitis induces acinar cell dedifferentiation to a duct-like exocrine progenitor state as a mechanism of recovery. The dedifferentiated progenitors proliferate to repopulate the gland before differentiating back into acinar cells under the |
| 요약 | In Chapter four, we utilized an inducible model of acinar specific D52 deletion (D52--/--) to investigate the impact of losing D52 expression, an early event in the onset of pancreatitis. Loss of D52 alone caused significant acinar cell damage, |
| 일반주제명 | Cellular biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
