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Synthetic Studies on the Marineosins and Other Related Complex Prodiginines
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Synthetic Studies on the Marineosins and Other Related Complex Prodiginines. |
| 개인저자 | Allred, Tyler Keith. |
| 단체저자명 | University of California, Los Angeles. Chemistry 0153. |
| 발행사항 | [S.l.]: University of California, Los Angeles., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 526 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438173040 |
| 학위논문주기 | Thesis (Ph.D.)--University of California, Los Angeles, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Patrick G. Harran. |
| 요약 | Chapter One provides an overview of complex prodiginine alkaloids: streptorubin, roseophilin, and the marineosins. This includes a brief discussion of the prototypical structural features of the prodiginine class of natural products, their isola |
| 요약 | We have developed a unique method of constructing the pyrrolophane core via a late stage phosphoryl-transfer mediated macroaldolization, which was utilized in the production of roseophilin. Chapter Two chronicles our efforts to adapt this approa |
| 요약 | Chapter Three discusses in detail our efforts to capitalize on the electron rich nature of the prodiginine core to engage a reactive functionality on the aliphatic chain and induce macrocyclization. Initial efforts were aimed at photoinduced ele |
| 요약 | Chapter Four details our efforts to utilize the reactivity discovered in model system studies, which culminated in the synthesis of marineosin A. The photoinduced rearrangement of pyridinophane N-oxides proved particularly powerful in the produc |
| 요약 | The readily apparent utility of the photoinduced rearrangement methodology caused us to revisit roseophilin. Chapter Five presents how the aforementioned rearrangement allows for facile access to the roseophilin pyrrolophane, which can be readil |
| 일반주제명 | Organic chemistry. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
