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Uncovering Structural Mechanisms Underlying GABA-A Receptor Activation and Drug Modulation
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Uncovering Structural Mechanisms Underlying GABA-A Receptor Activation and Drug Modulation. |
| 개인저자 | Tsao, Tzu-Wei. |
| 단체저자명 | The University of Wisconsin - Madison. Neuroscience. |
| 발행사항 | [S.l.]: The University of Wisconsin - Madison., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 182 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-11B(E). Dissertation Abstract International |
| ISBN | 9780438149014 |
| 학위논문주기 | Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Adviser: Cynthia Czajkowski. |
| 요약 | Gamma-aminobutyric acid type A receptors (GABAARs) are pentameric ligand-gated ion channels (pLGICs) that mediate neuronal inhibition in the brain. Defects in GABAAR signaling are associated with a variety of neurological diseases and psychiatri |
| 요약 | In this thesis, I used the substituted cysteine accessibility method and two-electrode voltage clamp electrophysiology in Xenopus laevis oocytes to demonstrate that orthosteric and allosteric non-competitive agonists stabilize the same open cha |
| 요약 | The results in this thesis provide new information about structural mechanisms underlying GABAAR activation and allosteric drug modulation. These data will provide useful information on targeting subunit interfaces in allosteric proteins for nov |
| 일반주제명 | Physiology. Biophysics. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
