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Detecting Cognitive, Functional and Behavioral Response to Donepezil in Alzheimer's Disease: The Role of Attention Tasks
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Detecting Cognitive, Functional and Behavioral Response to Donepezil in Alzheimer's Disease: The Role of Attention Tasks. |
| 개인저자 | Vila-Castelar, Clara. |
| 단체저자명 | City University of New York. Psychology. |
| 발행사항 | [S.l.]: City University of New York., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 88 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438261051 |
| 학위논문주기 | Thesis (Ph.D.)--City University of New York, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Nancy S. Foldi. |
| 요약 | Introduction: Cholinesterase Inhibitors (ChEIs) used in Alzheimer's Disease (AD) have modest effects, heterogeneous treatment response, and it has been difficult to detect treatment response. The standard research and clinical outcome measure, t |
| 요약 | Method: We conducted a longitudinal, open label donepezil trial assessing twenty-three participants with AD at baseline (T1), 6 weeks (T2) and 6 months (T3). Outcome measures were: a) Computerized measures of attention: Foreperiod Effect, Covert |
| 요약 | Results: Our findings show that attention measures at 6 weeks (T2) could predict 6-month (T3) global cognitive response to treatment better than any other memory or executive measure. Moreover, change in attention performance from baseline to 6 |
| 요약 | Conclusion: Our findings support our hypothesis that measures of attention under high-load conditions are sensitive to donepezil. Performance on these measures predicted long-term cognitive, functional, and behavioral response to ChEIs. |
| 일반주제명 | Psychology. Neurosciences. Clinical psychology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
