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Regulation of Effector CD4 T Cell Pathogenicity during Chronic Inflammation
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Regulation of Effector CD4 T Cell Pathogenicity during Chronic Inflammation. |
| 개인저자 | Shin, Boyoung. |
| 단체저자명 | The University of Alabama at Birmingham. Joint Health Sciences. |
| 발행사항 | [S.l.]: The University of Alabama at Birmingham., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 148 p. |
| 기본자료 저록 | Dissertation Abstracts International 80-01B(E). Dissertation Abstract International |
| ISBN | 9780438342866 |
| 학위논문주기 | Thesis (Ph.D.)--The University of Alabama at Birmingham, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Laurie E. Harrington. |
| 요약 | Effector CD4 T cells are essential for the balance between pro- and anti-inflammatory immune responses during homeostasis. Dysregulation of effector CD4 T cell responses results in chronic inflammatory disorders such as Inflammatory Bowel Diseas |
| 요약 | Different subsets of effector CD4 T cells utilize distinct metabolic pathways. We find that Th17 differentiation occurs in conjunction with a robust increase of ATP-linked mitochondrial respiration, which fuels energy demand. Interestingly, mito |
| 요약 | We also find that the differentiation state of CD4 T cells contributes to pathogenicity. A transcriptome analysis of effector CD4 T cells from chronic intestinal inflammation reveals that CD4 T cells exist as a spectrum of differentiation states |
| 일반주제명 | Immunology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
