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The Innate Effector Programmes of Invariant Natural Killer T-Cells
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | The Innate Effector Programmes of Invariant Natural Killer T-Cells. |
| 개인저자 | Sharma, Akshat. |
| 단체저자명 | The University of Wisconsin - Madison. Comparative Biomedical Science. |
| 발행사항 | [S.l.]: The University of Wisconsin - Madison., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 116 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438292437 |
| 학위논문주기 | Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Jenny E. Gumperz. |
| 요약 | T-cell effector functions exemplify adaptive immunity in that they 'adapt' to the threat at hand via a programme of antigen recognition, clonal expansion and subsequent contraction, and the generation of long-lived memory cells as insurance agai |
| 요약 | For the former, we stimulated clonal or short-term polyclonal lines of human iNKT cells with plate-bound ICAM-1-Fc in the absence of antigen-presenting cells, but in the presence or absence of exogenous IL-12p70 to investigate the role that LFA- |
| 요약 | Immunotherapy work was performed within an in vivo model of EBV-driven lymphomagenesis using humanised mice. iNKT cells appear to promote tumour clearance via the activation of endogenous MHC-restricted T-cells. Whether or not the iNKT-TCR is in |
| 요약 | Ultimately, the work curated here builds a case for the versatility of iNKT cells via their ability to be sensitive to changes in their milieu that do not always involve direct antigen presentation. This ability to 'stay current' is what posits |
| 일반주제명 | Immunology. Pathology. Virology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
