자료유형 | 학위논문 |
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서명/저자사항 | The Temporal Relationship between Synucleinopathy, Nigrostriatal Degeneration, and Neuroinflammation in the Alpha-Synuclein Preformed Fibril Model of Parkinson's Disease. |
개인저자 | Duffy, Megan Frances. |
단체저자명 | Michigan State University. Neuroscience - Doctor of Philosophy. |
발행사항 | [S.l.]: Michigan State University., 2018. |
발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
형태사항 | 195 p. |
기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
ISBN | 9780438286658 |
학위논문주기 | Thesis (Ph.D.)--Michigan State University, 2018. |
일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Caryl E. Sortwell. |
요약 | Numerous studies have documented risk variants in immune genes and increased microglial inflammatory markers in the parenchyma and biofluids of Parkinson's disease (PD) patients. Recently our lab has characterized a new rat model of PD induced b |
요약 | First, I histologically examined the time course of synucleinopathy, microgliosis and nigral degeneration at monthly intervals. Microglia in the vicinity of Lewy body-like inclusions display significantly increased cell body area and observable |
일반주제명 | Neurosciences. |
언어 | 영어 |
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