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In vivo Vascular Imaging with Photoacoustic Microscopy

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자료유형학위논문
서명/저자사항In vivo Vascular Imaging with Photoacoustic Microscopy.
개인저자Hsu, Hsun-Chia.
단체저자명Washington University in St. Louis. Biomedical Engineering.
발행사항[S.l.]: Washington University in St. Louis., 2018.
발행사항Ann Arbor: ProQuest Dissertations & Theses, 2018.
형태사항86 p.
기본자료 저록Dissertation Abstracts International 79-12B(E).
Dissertation Abstract International
ISBN9780438292338
학위논문주기Thesis (Ph.D.)--Washington University in St. Louis, 2018.
일반주기 Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Lihong V. Wang.
요약Photoacoustic (PA) tomography (PAT) has received extensive attention in the last decade for its capability to provide label-free structural and functional imaging in biological tissue with highly scalable spatial resolution and penetration depth
요약In this dissertation, one challenge was to quantitatively investigate red-blood-cell dynamics in nailfold capillaries with single-cell resolution PA microscopy (PAM). We recruited healthy volunteers and measured multiple hemodynamic parameters b
요약We next conducted a pilot study on sickle cell disease (SCD), measuring and comparing the parameters related to RBC dynamics between healthy subjects and patients with SCD. In the patient group, we found that capillaries tended to be more tortuo
요약As the last focus of this dissertation, we tackled the limited view problem in PAM by introducing an off-axis illumination technique for complementing the original detection view. We demonstrated this technique numerically and then experimentall
일반주제명Medical imaging.
Optics.
Acoustics.
언어영어
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