자료유형 | 학위논문 |
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서명/저자사항 | Probing Composition and Binding of Viruses with Charge Detection Mass Spectrometry. |
개인저자 | Dunbar, Carmen A. |
단체저자명 | Indiana University. Chemistry. |
발행사항 | [S.l.]: Indiana University., 2018. |
발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
형태사항 | 196 p. |
기본자료 저록 | Dissertation Abstracts International 80-02B(E). Dissertation Abstract International |
ISBN | 9780438373334 |
학위논문주기 | Thesis (Ph.D.)--Indiana University, 2018. |
일반주기 |
Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B.
Adviser: Martin F. Jarrold. |
요약 | Probing the composition of viruses can give insight into viral infectivity, antibody and virus binding affinity and protein stoichiometry. Unlike other commonly used characterization techniques, such as conventional mass spectrometry, and bioass |
요약 | CDMS was used to characterize three different viral systems. First, Sindbis virus (SINV) from two host vectors was studied to determine the role of glycan and lipid composition on viral infectivity. CDMS was used to measure the mass intact SINV |
요약 | Next Canine Parvovirus (CPV) was bound with fragment antibodies. The resulting capsid-antibody complex was measured using CDMS. Based on the mass shift between the unbound and bound CPV the total number of fragment antibodies bound was calculate |
요약 | Lastly, the stoichiometry of ejection proteins in Bacteriophage P22 was characterized. The stoichiometry of ejection proteins was probed by monitoring the mass shift between P22 mutants with ejection proteins and P22 mutants with one or all ejec |
일반주제명 | Analytical chemistry. |
언어 | 영어 |
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