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Identification of Bhlhe40 and Irg1 as Essential Regulators of the Inflammatory Response to Mycobacterium tuberculosis
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Identification of Bhlhe40 and Irg1 as Essential Regulators of the Inflammatory Response to Mycobacterium tuberculosis. |
| 개인저자 | Huynh, Jeremy Peter. |
| 단체저자명 | Washington University in St. Louis. Biology & Biomedical Sciences (Molecular Microbiology & Microbial Pathogenesis). |
| 발행사항 | [S.l.]: Washington University in St. Louis., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 155 p. |
| 기본자료 저록 | Dissertation Abstracts International 80-01B(E). Dissertation Abstract International |
| ISBN | 9780438312784 |
| 학위논문주기 | Thesis (Ph.D.)--Washington University in St. Louis, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Christina L. Stallings. |
| 요약 | Protective immune responses to Mycobacterium tuberculosis (Mtb) must induce bactericidal functions while minimizing damage to the lung. Such responses require precise control of pro- and anti-inflammatory factors to regulate the recruitment and |
| 요약 | We utilized genetically deficient mice to assess the roles of Bhlhe40 and Irg1 expression on control of in vivo Mtb infection. We found that Bhlhe40 enables protective immune responses to Mtb by restricting expression of the anti-inflammatory cy |
| 일반주제명 | Microbiology. Immunology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
