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Characterizing the Behavioral and Neural Mechanisms Underpinning Stress-enhanced Fear Learning, a Rodent Model of Post-traumatic Stress Disorder
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Characterizing the Behavioral and Neural Mechanisms Underpinning Stress-enhanced Fear Learning, a Rodent Model of Post-traumatic Stress Disorder. |
| 개인저자 | Tribble, Jennifer Elizabeth. |
| 단체저자명 | University of California, Los Angeles. Neuroscience 004F. |
| 발행사항 | [S.l.]: University of California, Los Angeles., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 162 p. |
| 기본자료 저록 | Dissertation Abstracts International 80-02B(E). Dissertation Abstract International |
| ISBN | 9780438414594 |
| 학위논문주기 | Thesis (Ph.D.)--University of California, Los Angeles, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B.
Adviser: Michael Fanselow. |
| 요약 | Post-Traumatic Stress Disorder (PTSD) is a complex, multi-faceted disease that affects a subset of individuals who undergo a traumatic experience. To understand the variety of psychological symptoms and their underpinning neural mechanisms, our |
| 요약 | In Chapter 2, I test for the effects of pair housing animals prior to, during, and following the acute stressor. Rodents are extremely social animals, and isolation housing has been shown to magnify or sufficiently cause effects of stress. There |
| 요약 | In Chapter 3, I test for the role of kappa opioid receptors (KORs) in the subsequent expression of PTSD-like phenotypes following an acute stressor. The KOR antagonist JDTic was administered immediately after trauma, then animals were tested for |
| 요약 | In Chapter 4, I use a variety of techniques to assess the neural mechanisms underlying the enhanced fear phenotype observed in our PTSD model. Specifically, I test for changes in excitatory receptors expressed in brain regions associated with fe |
| 요약 | Collectively, these studies serve as a beginning of exploring the many behavioral and neural mechanisms underlying our rodent model of PTSD. Future and subsequent studies may build off of this work to further characterize the PTSD-like phenotype |
| 일반주제명 | Neurosciences. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
