자료유형 | 학위논문 |
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서명/저자사항 | The Innate Regulatory Protein NLRP12 Maintains Commensal Bacterial Symbiosis, and Mitigates Intestinal Inflammation and Obesity. |
개인저자 | Chen, Liang. |
단체저자명 | The University of North Carolina at Chapel Hill. Microbiology and Immunology. |
발행사항 | [S.l.]: The University of North Carolina at Chapel Hill., 2018. |
발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
형태사항 | 181 p. |
기본자료 저록 | Dissertation Abstracts International 79-10B(E). Dissertation Abstract International |
ISBN | 9780438065871 |
학위논문주기 | Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018. |
일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisers: Jenny P-Y. Ting |
요약 | The nucleotide-binding domain, leucine-rich repeat containing proteins, also known as NOD-like receptors (NLRs), are pattern recognition receptors that play important roles in innate immunity (Aganna et al., 2002 |
요약 | Members of the NLR family can be categorized into two groups, the inflammasome-forming and non-inflammasome-forming NLRs. Inflammasomes are cytoplasmic multi-protein complexes that result in the catalytic cleavage of procaspase-1, generating cas |
요약 | NLRP12, a negative regulator of innate immunity, suppresses colon inflammation and inflammation-driven colorectal cancer (Allen et al., 2012b |
요약 | In the second part, we extended our knowledge of NLRP12 to diet induced obesity. We found NLRP12 expression was lower in patients with higher body mass index (BMI), and Nlrp12--/-- mice were more susceptible to high-fat-diet (HFD) induced obesit |
일반주제명 | Immunology. Microbiology. |
언어 | 영어 |
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