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The Innate Regulatory Protein NLRP12 Maintains Commensal Bacterial Symbiosis, and Mitigates Intestinal Inflammation and Obesity
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | The Innate Regulatory Protein NLRP12 Maintains Commensal Bacterial Symbiosis, and Mitigates Intestinal Inflammation and Obesity. |
| 개인저자 | Chen, Liang. |
| 단체저자명 | The University of North Carolina at Chapel Hill. Microbiology and Immunology. |
| 발행사항 | [S.l.]: The University of North Carolina at Chapel Hill., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 181 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-10B(E). Dissertation Abstract International |
| ISBN | 9780438065871 |
| 학위논문주기 | Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisers: Jenny P-Y. Ting |
| 요약 | The nucleotide-binding domain, leucine-rich repeat containing proteins, also known as NOD-like receptors (NLRs), are pattern recognition receptors that play important roles in innate immunity (Aganna et al., 2002 |
| 요약 | Members of the NLR family can be categorized into two groups, the inflammasome-forming and non-inflammasome-forming NLRs. Inflammasomes are cytoplasmic multi-protein complexes that result in the catalytic cleavage of procaspase-1, generating cas |
| 요약 | NLRP12, a negative regulator of innate immunity, suppresses colon inflammation and inflammation-driven colorectal cancer (Allen et al., 2012b |
| 요약 | In the second part, we extended our knowledge of NLRP12 to diet induced obesity. We found NLRP12 expression was lower in patients with higher body mass index (BMI), and Nlrp12--/-- mice were more susceptible to high-fat-diet (HFD) induced obesit |
| 일반주제명 | Immunology. Microbiology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
