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Sensing of HIV-1 by the Innate Immune System
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Sensing of HIV-1 by the Innate Immune System. |
| 개인저자 | Kumar, Swati. |
| 단체저자명 | College of Medicine - Mayo Clinic. Virology and Gene Therapy. |
| 발행사항 | [S.l.]: College of Medicine - Mayo Clinic., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 160 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438190627 |
| 학위논문주기 | Thesis (Ph.D.)--College of Medicine - Mayo Clinic, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Advisers: David Dingli |
| 요약 | TREX1, a major mammalian exonuclease, has been reported to degrade cytosolic immune-stimulatory DNA, including viral DNA generated during HIV-1 infection, but the dynamic range of its capacity to suppress innate immune stimulation is unknown, wh |
| 요약 | The nearly complete lack of innate immune induction despite equal to increased viral integration observed when the TREX1 protein level is experimentally elevated indicates that integration-competent genomes are shielded from cytosolic sensor-eff |
| 요약 | In the second part of this thesis, we investigate how perturbations of the intricately linked early post entry events of reverse transcription and uncoating and remodeling of viral cores affect sensing of viral nucleic acids. Reverse transcripti |
| 요약 | Taken together, our studies showed that the PAMPs sensed after viral entry contain DNA, are TREX1 and cGAS substrates, and are derived from incomplete reverse transcription products. In contrast, the experiments demonstrated that full-length int |
| 일반주제명 | Virology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
