상세정보
Export to Refworks부가기능
Engineering protein-based biomaterials using SpyTag/SpyCatcher technology
상세 프로파일
| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Engineering protein-based biomaterials using SpyTag/SpyCatcher technology. |
| 개인저자 | Williams, Danielle Marie. |
| 단체저자명 | Yale University. |
| 발행사항 | [S.l.]: Yale University., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 125 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438269507 |
| 학위논문주기 | Thesis (Ph.D.)--Yale University, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Lynne Regan. |
| 요약 | The ability to create linkages using SpyTag/SpyCatcher technology is a powerful tool for protein design and engineering. SpyTag, a 13-residue peptide, and SpyCatcher, a small protein, interact spontaneously to form a covalent isopeptide bond, wh |
| 요약 | One such project involves the design of stimulus-responsive hydrogels made entirely of protein components. We took advantage of the modular nature of TPR domains, which bind C-terminal peptides, to interact with cognate peptide cross-linkers to |
| 요약 | Other projects described in this text involve the development of geometric protein arrays. Such arrays have implications in signal amplification, biosensing, and enzyme scaffolding array. Using the modular, rod-like protein SasG and SpyTag/SpyCa |
| 요약 | Finally, we were able to functionalize 2D surfaces and microcapsules using SpyTag/SpyCatcher technology and a unique, amphiphilic bacterial hydrophobin, Bs1A. Bs1A self-assembles into a stable monolayer at both air-water and water-oil interfaces |
| 일반주제명 | Biochemistry. Biophysics. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
