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Innate Immune Responses in Zika Virus Control and Pathogenesis
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Innate Immune Responses in Zika Virus Control and Pathogenesis. |
| 개인저자 | Yockey, Laura Jeannette. |
| 단체저자명 | Yale University. |
| 발행사항 | [S.l.]: Yale University., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 200 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438269569 |
| 학위논문주기 | Thesis (Ph.D.)--Yale University, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Akiko Iwasaki. |
| 요약 | The female reproductive tract is an important site of viral exposure, in the case of sexually-transmitted infections. It must also protect and support normal pregnancy and development of the fetus, a process that requires complex immunological c |
| 요약 | First, we developed a mouse model of intravaginal ZIKV infection in order to investigate the innate immune control and pathogenesis of sexually-transmitted ZIKV. Epidemiological data demonstrate that ZIKV can be transmitted between sexual partne |
| 요약 | Next, we investigate the in vivo role for one of the candidate entry receptors for ZIKV, Axl. Identifying the cellular entry receptor for ZIKV is a critical step towards understanding the unique pathogenesis and tropism of ZIKV as a teratogenic |
| 요약 | Finally, we investigated how the IFN response of the fetus and fetal-derived placenta contributes to ZIKV-mediated pathology. This question has important implications for understanding the underlying pathogenesis and shared presentation of many |
| 일반주제명 | Immunology. Virology. Obstetrics. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
