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Gut Microbiota and Systemic Autoimmunity: Ameliorating Systemic Lupus Erythematosus through Diet, Microbiota, and Host Immune System Interactions
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Gut Microbiota and Systemic Autoimmunity: Ameliorating Systemic Lupus Erythematosus through Diet, Microbiota, and Host Immune System Interactions. |
| 개인저자 | Zegarra Ruiz, Daniel Fernando. |
| 단체저자명 | Yale University. |
| 발행사항 | [S.l.]: Yale University., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 184 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438269613 |
| 학위논문주기 | Thesis (Ph.D.)--Yale University, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Martin Alexander Kriegel. |
| 요약 | Autoimmune diseases are a major health problem affecting over 200 million people worldwide and represent one of the leading causes of death for women under 65 years old. Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that |
| 요약 | Alterations in the gut microbiota composition have been associated to autoimmune diseases, but it is largely unknown which specific bacterial communities are responsible for these effects. Interestingly, diet has been demonstrated to shape the g |
| 요약 | I utilized a spontaneous and inducible lupus model to dissect the role that diet, gut microbiota, and their interactions play in SLE. For the spontaneous model, I worked with toll-like receptor 7 transgenic (TLR7.1 Tg) mice that develop SLE-like |
| 요약 | In chapter II, I demonstrate the role that gut microbiota plays on SLE. Fecal 16S rDNA sequencing was performed and I identified that murine SLE models developed intestinal dysbiosis. Depletion of the gut microbiota reduced mortality and pathoge |
| 요약 | In chapter III, I identify a key bacterial strain that exacerbates SLE. Through culture of internal organs I revealed that L. reuteri (LR) translocated outside the gut in SLE-prone mice and in cohoused wild type littermates. In addition, 16S rDN |
| 요약 | Finally, in chapter IV, I fed a RS enriched diet to our lupus mouse models before onset of disease to assess if diet can ameliorate systemic autoimmunity through modulation of the gut microbiome and LR outgrowth inhibition. Fecal 16S rDNA sequen |
| 요약 | In conclusion, the research outline in this thesis contributes to a better understanding of the effects of RS on lupus pathogenesis through modulation of the gut microbiome and suppression of pathobionts, representing a safer approach to amelior |
| 일반주제명 | Immunology. Health sciences. Microbiology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
